Exercise and Cancer Sport und Krebs 2011

LOGIC-trial // Welcome

Long-term effects of lifestyle intervention in Obesity and Genetic Influence in Children


Aim

The aim of the LOGIC trial (Long-term effects of Lifestyle intervention and Genetic Influence in Children) is to investigate the short-, middle-, and long-term associations between body weight (loss) and polymorphisms in adiposity relevant genes, cardio-metabolic parameters, lifestyle and quality of life. The trial runs since January 2006 and up to the end of 2013 nearly 1.500 children could be included.

Participants

Participants are 8 to 19 year old children and adolescents with overweight or obesity, who started a standardized in-patient weight loss therapy that focuses on a calorie restricted diet, adequate physical activity and behavior therapy at the rehabilitation center Klinik Schönsicht, Berchtesgaden, Germany.

Procedure

The study is separated into two main parts:

In-patient therapy

Participants were recruited on their arrival day at the rehabilitation center. Blood samples and anthropometrical measurements weretaken and questionnaires on physical activity, dietary intake and/or quality of life werecompleted at the beginning and the end of the therapy (after 4 to 6 weeks).

Follow-up

Follow-up measurements took place 6 months, 1 year, 2 years, 5 years and 10 years after the in-patient therapy. Participants once more completed the study questionnaires and visited their general practitioner for examination of anthropometry, blood pressure and Tanner status. At the 5 year and 10 year follow-up examination blood parameters were collected to analyze cardiometabolic risk parameters, inflammation markers and adipokines.

Support

This work is supported by the Else Kröner-Fresenius-Stiftung and the Rentenversicherung Bayern Süd and the German Center for Cardiovascular Research, partner site Munich Heart Alliance.

Publications

Journals

Congress articles

Information drucken

Supporting societies

Klinik Schönsicht Berchtesgaden
Die Else Kröner-Fresenius-Stiftung
Die Deutsche Rentenversicherung Bayern Süd
© Projektleitung "LOGIC-Studie"