The aim of the LOGIC trial (Long-term effects of Lifestyle intervention and Genetic Influence in Children) is to investigate the short-, middle-, and long-term associations between body weight (loss) and polymorphisms in adiposity relevant genes, cardio-metabolic parameters, lifestyle and quality of life. The trial runs since January 2006 and up to the end of 2013 nearly 1.500 children could be included.

Participants are 8 to 19 year old children and adolescents with overweight or obesity, who started a standardized in-patient weight loss therapy that focuses on a calorie restricted diet, adequate physical activity and behavior therapy at the rehabilitation center Klinik Schönsicht, Berchtesgaden, Germany.

The study is separated into two main parts:

In-patient therapy

Participants were recruited on their arrival day at the rehabilitation center. Blood samples and anthropometrical measurements weretaken and questionnaires on physical activity, dietary intake and/or quality of life werecompleted at the beginning and the end of the therapy (after 4 to 6 weeks).

Follow-up

Follow-up measurements took place 6 months, 1 year, 2 years, 5 years and 10 years after the in-patient therapy. Participants once more completed the study questionnaires and visited their general practitioner for examination of anthropometry, blood pressure and Tanner status. At the 5 year and 10 year follow-up examination blood parameters were collected to analyze cardiometabolic risk parameters, inflammation markers and adipokines.

This work is supported by the Else Kröner-Fresenius-Stiftung and the Rentenversicherung Bayern Süd and the German Center for Cardiovascular Research, partner site Munich Heart Alliance.

Journals

• Rank M, Wilks DC, Foley L, Jiang Y, Langhof H, Siegrist M, Halle M: Health-Related Quality of Life and Physical Activity in Children and Adolescents 2 Years after an Inpatient Weight-Loss Program. J Pediatr. 2014 Jul 16. pii: S0022-3476(14)00495-8. doi: 10.1016/j.jpeds.2014.05.045.
• Rank M, Siegrist M, Wilks DC, Langhof H, Wolfarth B, Haller B, Koenig W, Halle M: The Cardio-Metabolic Risk of Moderate and Severe Obesity in Children and Adolescents. J Pediatr. 2013 Jul;163(1):137-42. doi: 10.1016/j.jpeds.2013.01.020.
• Siegrist M, Rank M, Wolfarth B, Langhof H, Haller B, Koenig W, Halle M: Leptin, adiponectin, and short-term and long-term weight loss after a lifestyle intervention in obese children. Nutrition. 2013 Jun;29(6):851-7. doi: 10.1016/j.nut.2012.12.011.
• Wilks DC, Rank M, Christle J, Langhof H, Siegrist M, Halle M: An inpatient lifestyle-change programme improves heart rate recovery in overweight and obese children and adolescents (LOGIC Trial). Eur J Prev Cardiol. 2012 Oct 29
• Rank M, Siegrist M, Wilks DC, Haller B, Wolfarth B, Langhof H, Halle M: Long-term effects of an inpatient weight-loss program in obese children and the role of genetic predisposition - Rationale and design of the LOGIC-trial. BMC Pediatr. 2012 Mar 19;12(1):30
• Rank M, Siegrist M, Langhof H, Halle M: Effekte einer Lebensstilintervention auf den BMI-SDS und die Lebensqualität im Follow-up über 12 Monate bei übergewichtigen und adipösen Kindern. Journal für Ernährungsmedizin Sep 2011
• Holzapfel C, Siegrist M, Rank M, Langhof H, Grallert H, Baumert J, Irimie C, Klopp N, Wolfarth B, Illig T, Hauner H and Halle M: Association of a melatonin receptor 1B (MTNR1B) gene variant with fasting glucose and HOMA-B in children and adolescents of high BMI-SDS groups. European Journal of Endocrinology 2011;164:205.
• Siegrist M, Pertl A, Schlenz I, Langhof H, Wolfarth B, Halle M: Stationäre Adipositastherapie bei adipösen Kindern und Jugendlichen – Interventionsergebnisse und Follow-up nach sechs Monaten. Journal für Ernährungsmedizin 2009; 11(1), 22.

Congress articles

• Siegrist M, Geilhof B, Langhof H et al. Long term effects of an inpatient lifestyle intervention program on lipid levels and physical activity in overweight and obese children, EuroPRevent, Lissabon, May, 2015
• Siegrist M, Geilhof B, Heitkamp M et al. Langfristige Effekte eines stationären Adipositas-Programms – 5-Jahres-Ergebnisse der LOGIC-Studie, Diabetes Herbsttagung und Adipositas-Jahrestagung, Leipzig, 2014
• Wolfarth B, Göhl N, Pertl A, Siegrist M, Langhof H, Halle M: Ergebnisse eines stationären Therapieprogramms bei adipösen Kindern unter besonderer Berücksichtigung von genetischen Polymorphismen im TNF-alpha, Adiponectin- und Leptinrezeptor-Gen (Deutsche Zeitschrift für Sportmedizin, 62 (7/8), 2011.
• Wilks DC, Rank M, Harl D, Siegrist M, Langhof H, Halle M: Körperliche Aktivität während einer stationären Adipositastherapie – eine Pedometer Substudie des LOGIC-Trials. Deutsche Zeitschrift für Sportmedizin, 62 (7/8), 2011.
• Rank M, Siegrist M, Wilks D, Langhof H, Halle M. Körperliche Aktivität übergewichtiger und adipöser Kinder und Jugendlicher 12 Monate nach einer stationären Adipositastherapie – LOGIC-Studie. Deutsche Zeitschrift für Sportmedizin, 62 (7/8), 2011.
• Rank M, Siegrist M, Wilks DC Langhof H, Koenig W & Halle M. Relationship between fitness and leptin levels in overweight and obese children. EuroPRevent, Geneva, Switzerland, April 2011.
  
• Wilks DC, Rank M, Siegrist M, Christle J, Langhof H & Halle M. Heart rate recovery improves after inpatient weight loss therapy in overweight and obese children and adolescents (LOGIC-trial). EuroPRevent, Geneva, Switzerland, April 2011.
• Rank M, Siegrist M, Wilks DC et al. (2010) Übergewichtige, adipose und extreme adipose Kinder und ihr metabolisches Risikoprofil. 26. Jahrestagung der Deutschen Adipositas-Gesellschaft, November 2010, Berlin, Germany.
• Rank M, Siegrist M, Langhof H, Halle M. Kurz- und langfristige Effekte einer stationären Adipositas-Therapie auf die gesundheitsbezogene Lebensqualität bei übergewichtigen und adipösen Kindern und Jugendlichen. The 18th international conference of eating disorders. Oct 2010, Alpbach, Austria.